There were victories for Saints loanees Harrison Reed and Guido Carrillo on a busy weekend of action across the continent.
Midfielder Reed played the duration in an eye-catching performance for Blackburn who rose to ninth in the Championship table with a 1-0 over Bolton.
Bradley Dack’s goal settled the result at the Macron Stadium to end Bolton’s run of six home league wins in a row against them.
Reed was the only Saints youngster to feature in the Championship over the weekend with Sam McQueen and Josh Sims both unused substitutes in defeats for Middlesbrough and Reading respectively.
Further down the pyramid, Jake Hesketh’s Burton Albion were beaten by Wycombe Wanderers courtesy of Adebayo Akinfenwa’s 200th goal in English football; playmaker Hesketh was replaced by Devante Cole 34 minutes from time.
Young full-back Harrison Davis meanwhile featured for 88 minutes of Tiverton Town’s 3-3 draw with Metropolitan Police in the Southern Premier League.
Elsewhere in Europe, Jordy Clasie played the full 90 minutes as Feyenoord were held to a 1-1 draw by Willem II in the Eredivise; the result leaves the Rotterdam club seven points behind leaders PSV who have won all seven of their opening matches.
In Spain, both Carrillo and Boufal were on the scoresheet for Léganes and Celta Vigo.
Argentine Carrillo netted the winner in the Madrid derby against Rayo Vallecano, smartly turning in a low cross first-time into the far corner to lift Mauricio Pellegrino’s side off the bottom of La Liga.
In Seville, Boufal’s fine individual effort – running from the halfway line before curling beyond the goalkeeper – proved to be just a consolation for Celta Vigo who lost 2-1 against the surprise early pacesetters.