October saw Saints travel to the San Siro to face Inter Milan and also kick-start their EFL campaign with a win over Sunderland.
The month started with a goalless stalemate away at Premier League champions Leicester City, which extended Saints' unbeaten run to six games.
That was soon seven when Charlie Austin bagged a brace against his former club Burnley and Nathan Redmond also netted to secure a 3-1 victory at St Mary's.
Four days later, Claude Puel's men travelled to the San Siro to take on Inter Milan in the Europa League. And despite dominating proceedings in Italy, Antonio Candreva's 66th minute strike earned the hosts all three points.
The fixtures didn't get any easier as a trip to the Etihad then followed. But Saints soon had the lead thanks to Redmond, though his first-half effort was eventually cancelled out by Kelechi Iheanacho to ensure a share of the points.
Puel made a number of changes to his starting XI for the next game: an EFL Cup clash at home to Sunderland.
Academy graduate Olufela Olomola made his first-team debut as Sofiane Boufal's stunner - and eventual Goal of the Season winner - sent Saints through to the next round.
The month then concluded with the visit of Chelsea, where goals from Eden Hazard and Diego Costa saw Puel's men fall to a 2-0 defeat.
Sunday 2nd Leicester City (a) D 0-0
Sunday 16th Burnley (h) W 3-1
Thursday 20th Inter Milan (a) L 1-0 (Europa League)
Sunday 23rd Manchester City (a) D 1-1
Wednesday 26th Sunderland (h) W 1-0 (EFL Cup)
Sunday 30th Chelsea (h) L 0-2