Claude Puel has indicated he could freshen up his team for the trip to Middlesbrough.
Southampton visit the Riverside Stadium tomorrow, for what will be the team’s third game in the past week.
With another two to follow in the following week, Puel is having to guard against fatigue among his players.
"We made two strong games on the physical side, with a lot of intensity,” he said. "It will be important to see all of this with the players and their recovery.
"Middlesbrough did not play [since Monday] and it will be important to play with a team that is physically fit, with good intensity and good possibilities to make a good result.
“A good recovery is important, especially as afterwards we have to play a game against Manchester United and then finish at home to Stoke.
“It's a difficult schedule and it's important with the starting players to make sure you have a team that is fresh and that has good possibilities to maintain a good rhythm and intensity to try to win the game.
"We've got to try to put in place a team with a good balance and a good possibility to win the game away against Middlesbrough."