Ahead of Sunday’s trip to Anfield, take a look back at five memorable away matches against Liverpool.
From 1960 to the current season, we revisit Southampton's best wins on Merseyside.
31st August 1960: Liverpool 0-1 Southampton (O’Brien)
Tommy Mulgrew threaded the ball through to George O’Brien to slot home in the 65th minute, as Ted Bates’ side got a win over Bill Shankly’s men on Merseyside.
It was a double success for the hosts who had also beaten Liverpool 4-1 a week earlier at The Dell, in a game that O’Brien had also scored in, alongside John Sydenham, Terry Paine, and Derek Reeves.
Southampton team: Ron Reynolds, Ron Davies, Tommy Traynor, Brian Clifton, John Page, Cliff Huxford, Terry Paine, George O’Brien, Derek Reeves, Tommy Mulgrew, John Sydenham
7th February 1998: Liverpool 2-3 Southampton (Hirst 2, Ostenstad)
Saints claimed their first win at Anfield for 17 years thanks to a brace of goals from David Hirst.
The striker grabbed his first of the game from the penalty spot after nine minutes to give the visitors a perfect start to the match.
Liverpool forward Michael Owen levelled up before the break to make it 1-1 at half-time.
It would go on to be another late show, with Egil Ostenstad sweeping home an assist from Hirst to make it 2-1, before the Norwegian returned the favour for Hirst to smash in the third past David James.
Owen reduced the arrears in stoppage time, but Dave Jones’ Saints were deserved winners on the day.
Southampton team: Paul Jones, Jason Dodd, Lee Todd, Kevin Richardson, Ken Monkou, Claus Lundekvam (Richard Dryden 49), John Beresford, Matt Oakley (Andy Williams 15), David Hughes, David Hirst, Kevin Davies (Egil Ostenstad 39)
13th December 2003: Liverpool 1-2 Southampton (Ormerod, Svensson)
Southampton leap-frogged Liverpool in the Premiership table as Gordon Strachan's side secured a deserved win at Anfield.
Brett Ormerod scored in the second minute - his third goal in two games - to give Southampton the lead and Michael Svensson added a second with a header on 64 minutes.
Emile Heskey gave Liverpool hope with a scrambled effort, but Gerard Houllier's side were unable to contrive an equaliser as they slipped to a fourth home league defeat of the season.
Southampton team: Antti Niemi, Jason Dodd, Michael Svensson, Claus Lundekvam (Chris Marsden 41), Danny Higginbotham, Paul Telfer, Rory Delap, David Prutton, James Beattie (Agustin Delgado 81), Marian Pahars (Fabrice Fernandes 63), Brett Ormerod
21st September 2013: Liverpool 0-1 Southampton (Lovren)
Dejan Lovren’s first goal for Saints earned all three points against the league leaders on Merseyside.
The Croatian centre back headed home Adam Lallana’s corner on 53 minutes to earn the visitors their first victory at Anfield for nearly ten years.
It was a professional performance from start to finish by Saints, who were co-incidentally the last team to beat the Reds with Liverpool having been on a 12 match unbeaten run going into this game.
Southampton team: Artur Boruc, Nathaniel Clyne, Jose Fonte, Dejan Lovren, Luke Shaw, Victor Wanyama, Morgan Schneiderlin, Adam Lallana (c) (James Ward-Prowse 75), Jay Rodriguez (Jack Cork 88), Rickie Lambert (Steven Davis 66), Dani Osvaldo
25th January 2017: Liverpool 0-1 Southampton (Long)
Shane Long’s stoppage-time strike ensured a 2-0 win on aggregate and a place in the EFL Cup Final.
With Virgil van Dijk missing through injury, 23-year-old Jack Stephens came into the heart of defence with Maya Yoshida and put in a sterling performance to keep Liverpool at bay.
Substitute Josh Sims was then the architect of the match-winning strike. The Academy graduate ran the length of the pitch to break from defending a corner and tee up Long, who rifled in low past Loris Karius to spark jubilant scenes in the away end.
Southampton team: Fraser Forster, Cédric, Jack Stephens, Maya Yoshida, Ryan Bertrand, James Ward-Prowse (Pierre-Emile Højbjerg 59), Oriol Romeu, Steven Davis (c), Nathan Redmond (Josh Sims 81), Dušan Tadić, Jay Rodriguez (Shane Long 45)