We take a look back on five of the most memorable games against Chelsea.
Ahead of Tuesday night's visit to Stamford Bridge, relive five of Saints' memorable victories over Chelsea.
Chelsea 1-3 Southampton (October 2015)
Ronald Koeman’s Southampton side sealed a memorable comeback victory over Chelsea at Stamford Bridge in 2015.
The then Premier League champions took an early lead through Willian’s free-kick before Steven Davis drove in an equaliser before the break.
The second half was then all Saints, as goals from Sadio Mané and Graziano Pellé confirmed a memorable day out in west London.
Southampton team: Stekelenburg, Soares, Fonte, van Dijk, Bertrand, Romeu (Ward-Prowse), Wanywama, Davis, Mané (Yoshida), Tadić (Rodriguez), Pellé
Southampton 2-1 Chelsea (March 2013)
Jay Rodriguez opened the scoring on 23 minutes for Mauricio Pochettino’s men after fine work from Rickie Lambert and Steven Davis.
John Terry then headed in from a corner to level before the break, but Saints responded immediately and Lambert’s 25-yard free-kick restored the lead on 35 minutes.
The win saw Southampton climb to 13th in the table after establishing a four-point safety cushion from the drop zone.
Southampton team: Boruc (K Davis), Clyne, Yoshida, Hoojveld, Shaw, Schneirderlin, S Davis (Fox), Cork, Puncheon (Ward-Prowse), Lambert, Rodriguez
Chelsea 2-4 Saints (January 2002)
James Beattie opened the scoring after only seven minutes at Stamford Bridge. The striker curled a 35-yard free-kick into the top corner before Eidur Gudjohnsen and Jimmy Floyd Hasselbaink then struck to pull the hosts ahead before the break.
Marian Pahars then outpaced John Terry on 56 minutes to break free and level under Carlo Cudicini before Chris Marsden headed in just ten minutes later to reinstate Saints’ lead.
On 73 minutes Pahars teed up Beattie who netted with a left-footed volley to seal Saints’ first away win, coming from behind, since 1994.
Southampton team: Jones, Dodd, Lundekvam, Williams, Bridge, Telfer, Delap, Svensson, Marsden, Pahars (Ormerod), Beattie
Southampton 3-2 Chelsea (November 2000)
James Beattie was the two-goal hero in this game, with his last-minute effort decisive in a five-goal thriller at The Dell.
The Saints striker notched his first after just three minutes when he knocked in Wayne Bridge's excellent cross at the far post which followed on from some neat link up between Bridge and Marian Pahars.
Jo Tessem scooped the ball in for 2-0 past the half hour, while Pahars had two spot-kick appeals turned down before Chelsea pulled one back through Dennis Wise.
Gus Poyet looked to have snatched a draw for the Blues on 77, but after Wise had brought down Pahars in stoppage time at the end of the game, Beattie thundered home a 28-yard free kick to seal the victory.
Southampton team: Jones, Dodd, Lundekvam, Richards, Bridge, Tessem, Oakley (K Davies), El-Khalej, Marsden, Pahars, Beattie
Southampton 3-1 Chelsea (December 1993)
Saints headed into this game on a run of five straight defeats, so were given some much needed Christmas cheer when Tommy Widdrington volleyed home from Micky Adams' cross after 12 minutes.
Mark Stein levelled matters just before half time, but the hosts hit back on 65 minutes when Iain Dowie slid the ball home from Paul Allen's cutback.
The win was made safe two minutes from time when Frankie Bennett sprinted through the Chelsea defence to smash the ball home for a win which would help Saints to avoid relegation by a point later that season.
Southampton team: Beasant, Dodd, Adams, Benali, Wood, Reid (Bennett), Le Tissier, Widdrington, Maddsion, Dowie, Allen