Manolo Gabbiadini will be missing for the second game in succession tomorrow night, but Claude Puel has every faith in whoever he chooses to replace him.
Gabbiadini missed the 0-0 draw with Bournemouth last Saturday, with the Saints boss starting Jay Rodriguez, who was denied a goal by an offside flag, in his place.
Puel also introduced Shane Long from the bench in the second half, and again has both men to choose from when Crystal Palace visit St Mary's.
"I haven't decided who will start yet, but I have confidence in all my players, like Shane and Jay, to make a good game and to bring a good level for the team," he said.
With Wednesday's game representing the second of three matches in an eight-day spell, Puel is keeping a close eye on his players' freshness.
"I need to look at my players," he said. "Of course, it's important to have good possibilities on the pitch and on the bench also.
"We know it's important for the substitutes to give good support for their teammates. Perhaps some players are a little tired and we will see this."