Claude Puel is still waiting for the results of a scan on Virgil van Dijk to see whether the defender can play against Liverpool, but Steven Davis could return.
Saints visit Liverpool for the second leg of their EFL Cup semi-final, as they take a 1-0 advantage with them to Anfield.
But Puel is still uncertain as to whether new team captain van Dijk will be available, after he picked up a knock in Sunday’s 3-0 win over Leicester City.
However, freshly-appointed club captain Davis could be fit enough to feature, after recovering from an injury that has kept him out of the last few games.
"van Dijk, he is having a scan and I am waiting for the results at the moment,” said Puel.
“It was a good kick on his ankle, and he could not continue in the game yesterday.
"It’s not serious, but I don’t know if he can participate in this game. We will see in the next days before the game.”
Puel added: "It's better for Davis. We will see tomorrow in the training session if he can participate in this game or not."