Steven Davis is set to miss the Emirates FA Cup replay with Norwich City, while Virgil van Dijk and Ryan Bertrand are both doubts for the match.
Southampton welcome the Canaries on Wednesday night (7.45pm GMT), following a 2-2 draw at Carrow Road first time up, as the two sides fight it out for the right to host Arsenal in the fourth round of the competition.
Saints will again be without midfielder Davis, who missed Saturday’s Premier League trip to Burnley because of injury, while van Dijk and Bertrand both have slight issues that need to be assessed.
"For this game, Davis will not be available,” Saints boss Claude Puel said. “Sofiane Boufal also.
“We will see on some players who have some pain, like Virgil and Bertrand. We will see this, and we have long injuries of course, like Austin and McCarthy, Hesketh and Targett.”