Southampton or Wigan will face Manchester City or Liverpool away from home in the fifth round of the FA Youth Cup.
The winners of Wednesday night's FA Youth Cup fourth round tie at DW Stadium will face a trip to Manchester City or Liverpool in the next round.
Saints head to Wigan on Wednesday, the same night the first team takes on Liverpool in the EFL Cup semi-finals, looking to reach round five.
Craig Fleming's side knocked out Manchester United at Old Trafford in their third round tie back in December.
Saints will now hope to see off Wigan to set up another exciting trip in the FA Youth Cup. Man City and Liverpool face one another on Wednesday 18th January.
Clubs must play their fifth-round ties by Saturday 4th February to complete the line-up for the quarter-finals.