Southampton trio James Ward-Prowse, Jack Stephens and Nathan Redmond could be back in action on Monday evening.
After their dramatic win against their Italian counterparts at St Mary's last Thursday, in which Stephens scored the winning goal, the trio have jetted out to France with England Under-21s.
They will be up against their French counterparts as they continue preparing for next summer's Under-21 European Championships.
The game gets under way at 7.45pm GMT, and will be shown live on BT Sport.
Stephens, Ward-Prowse and Redmond will return to the south coast after the game, as Saints prepare for their clash with Liverpool this weekend.