Southampton's Ryan Bertrand was an unused substitute in England's 3-0 win over Scotland.
Tottenham's Danny Rose was preferred at left-back, ahead of the Saints regular, as the hosts enjoyed a night to remember in the World Cup qualifier at Wembley.
England didn't have things their own way during the first half, but did manage to scrape a lead going into the break, thanks to Daniel Sturridge's superb header.
The Three Lions then stormed away from their rivals after the interval, with former Saints skipper Adam Lallana doubling the lead, as he guided in another headed effort.
And England were in complete cruise control when Gary Cahill completed a hat-trick of headers for the team, flicking in a Wayne Rooney corner just after the hour mark.
The result means England retain the lead in Group F, with ten points from their first four games of the qualifying campaign, ahead of the 2018 finals, in Russia.
Gareth Southgate's men will now play host to Spain, in a friendly match, next Tuesday.