Saints recorded a comfortable win over Dutch lower-leaguers EHC Hoensbroek in their opening pre-season friendly and the first game under Ronald Koeman.
The impressive Sam McQueen gave the visitors an 11th-minute lead, with Calum Chambers doubling the advantage just before the break.
Billy Sharp, on as one of 11 half-time substitutions, made it three from the penalty spot before Steven Davis scored the pick of the bunch soon afterwards to round off the scoring.
Koeman’s first starting XI as Saints boss contained a mixture of experience and youth, as the likes of Kelvin Davis, José Fonte and Jack Cork were joined in the team by Jake Sinclair, Jordan Turnbull and McQueen.
José Fonte started as captain, while their was a place up front for Emmanuel Mayuka following his season-long loan spell with French side Sochaux last year.
In front of a packed crowd at the SportPark de Dem, Saints unsurprisingly dominated the opening stages against the fifth-tier outfit.
Koeman’s side duly took the lead on 11 minutes as McQueen, one of six teenagers in the starting XI, hit a drive that deflected off an EHC defender and looped over goalkeeper Tom Grootaers.
The home side could well have won a penalty shortly afterwards as Ron Starmans collided with Saints ‘keeper Davis in the box, but the referee opted not to award the spot-kick.
McQueen turned provider on 14 minutes as he crossed for fellow academy graduate Sinclair, but the wide-man scooped his effort well over the goal.
Ward-Prowse then saw a curling effort go just wide of the post, while Harrison Reed’s drive was parried well by Grootaers just after the half-hour.
Fonte and Sinclair both headed over as Saints began to assert themselves further in the closing stages of the half, while Mayuka spurned a trio of chances as he volleyed off target before being denied by two excellent saves.
The second goal duly arrived a minute before the break as McQueen’s inswinging corner from the right was headed into the top corner at the near post by Chambers.
Saints nearly scored a copycat third as another McQueen corner from the right found Chambers in an identical position, but this time he headed into the side-netting as the half came to a close.
HALF-TIME: EHC HOENSBROEK 0-2 SOUTHAMPTON
Koeman made wholesale changes at the break, sending out a completely different team for the second half.
Among them was new signing Dušan Tadić, making his unofficial debut for the team, while youngsters Jason McCarthy, Jake Flannigan and Matt Targett made their first-ever appearances for the senior side.
After a quiet start to the half, the game came back to life on the hour mark as Steven Davis was tripped in the box, offering Billy Sharp the chance to mark his first Saints appearance in the best part of two years with a goal.
And the striker, who spent much of the past two seasons out on loan, duly obliged by sending Grootaers the wrong way from the penalty spot.
Saints then scored a second in the space of three minutes when, after Sam Gallagher’s header had hit the post, second-half skipper Davis rocketed home from all of 25 yards.
The game soon settled back down, with Saints no less dominant but EHC defending much more resolutely.
18-year-old Flannigan did flash a low shot wide on 78 minutes, while Sharp went close soon afterwards with a header that bounced just wide from an inswinging Tadić free-kick.
There would be no further goals, as the Koeman reign began with a comfortable win and pre-season got off to a victorious start.
FULL TIME: EHC HOENSBROEK 0-4 SOUTHAMPTON
Southampton: Kelvin Davis (Paulo Gazzaniga 46), Calum Chambers (Jason McCarthy 46), José Fonte (Jack Stephens 46), Jordan Turnbull (Jos Hooiveld 46), Nathaniel Clyne (Matt Targett 46), Jack Cork (Jake Flannigan 46), Harrison Reed (Steven Davis 46), James Ward-Prowse (Dušan Tadić 46), Jake Sinclair (Lloyd Isgrove 46), Sam McQueen (Billy Sharp 46), Emmanuel Mayuka (Sam Gallagher 46).
Goals: McQueen (11), Chambers (44), Sharp (pen 62), S. Davis (64)
EHC Hoensbroek: Tom Grootaers, Omar El Achkar (Mitch Reintjens 60), Olaf Rompelberg, Mitch Kok (Dennis Jacobs 75), Marc Eberle (Tom Maas 46), Karim Mahmoud (Fabio Sarli 46), Bastiaan Weiser, Peter Jan Erkens, Ron Starmans (Semmy Meijer 75), Muslum Karabulut (Ike Schrijnemakers 60), Michele Meerburg (Haddadi Imad 60). Unused substitute: Tom Delarosette (GK).